Deregulations of RNA Pol II Subunits in Cancer

Deregulated transcription is a well-known characteristic of cancer cells, with differentially expressed genes being common feature several cancers. Often, deregulated consequence alterations in factors (TFs), which play crucial role gene expression and can act as tumour suppressors or proto-oncogenes. In eukaryotic organisms, carried out by three distinct RNA polymerase complexes: Pol I, II, III. specifically, responsible for transcribing messenger (mRNA), the protein coding part genome, well long non-coding RNAs (lncRNAs). While there considerable research on impact specific development, lack studies focusing defects within complexes their subunits. This review aims to shed light particular II complex highlight deregulation its subunits that have significant prognosis, survival. By providing comprehensive overview our current understanding cancer, this emphasizes importance further area. It suggests exploring these subunits’ deregulations could lead identification valuable biomarkers potential therapeutic targets, making it topic collective interest.